Investigación que realiza / Research Focus
Estoy interesada en estudiar el papel que tienen las hormonas tiroideas en la reproducción femenina y en el metabolismo. Usando como modelo animal a la coneja, realizamos técnicas histológicas e inmunodetección para determinar posibles cambios estructurales y en la expresión de algunas proteínas en los tejidos, tanto reproductivos como relacionados con el metabolismo, ante las variaciones en los niveles de dichas hormonas.


I am interested in studying the role of thyroid hormones in female reproduction and metabolism. By using female rabbits as animal models, we carry out histological and immunodetection techniques in order to determine possible structural changes and changes in the expression of certain proteins in different types of tissues, including those related to metabolism or reproduction, given the variation in the levels of such hormones.
Dra. Estela Cuevas Romero
Laboratorio de Endocrinología, Centro Tlaxcala de Biología de la Conducta, UATx.

cuevasestela@hotmail.com
ecuevas@uatx.mx
Sociedades Científicas / Scientific Societies
Socio regular de la Sociedad Mexicana de Ciencias Fisiológicas, A.C. 2007 a la fecha.

Socio regular de la Society for Neuroscience (SFN), de 2009 a la fecha.

Miembro titular de la Academia de Biología de la Reproducción A.C. de 2013 a la fecha.
Línea de Generación y Aplicación del Conocimiento (LGAC)/ Line of Generation and Application of Knowledge (LGAK)

Biomedicina/ Biomedicine
Licenciatura/ Degree: Químico Farmacéutico Biológo, Universidad Veracruzana

Maestría/ Master: Neuroetología, Universidad Veracruzana

Doctorado/ Doctorate: Neurociencias y Biología Celular y Molecular, Universidad Miguel Hernández, Alicante, España


Postdoctorado / Postdoctoral Positions: Instituto de Investigaciones Biomédicas, UNAM

Diplomado en Divulgación Científica, UNAM

Perfil PROMEP

SNI nivel 2
Inicio/ Home
Otros Investigadores / Other Researchers
En prensa. Yadira Díaz-Aguila, Estela Cuevas-Romero, Francisco Castelán, Margarita Martínez-Gómez, Jorge Rodríguez-Antolín, and Leticia Nicolás-Toledo. Chronic stress and high-sucrose intake elicit distinct effects morphometric in the adrenal gland of post-weaned rats. Journal of Physiological Sciences

En prensa. Rodríguez-Castelán J, Méndez-Tepepa M, Rodríguez-Antolín J, Castelán F, Cuevas-Romero E. Hypothyroidism affects lipid and glycogen content and peroxisome proliferator-activated receptor beta expression in the ovary of the rabbit. Reprod Fertil Dev. 2018 May 3.

En prensa. Sánchez-García O, López-Juárez R, Rodríguez-Castelán J, Corona-Quintanilla DL, Martínez-Gómez M, Cuevas-Romero E, Castelán F.Hypothyroidism impairs somatovisceral reflexes involved in micturition of female rabbits. Neurourol Urodyn. 2018 Apr 17.

2018. Lara-García O, Lara-García M, Perez-Hernandez D, Cuevas E, Martínez-Gómez M, Pacheco P. Spinal cord neuronal components involved in the reflex activity of female rat pubococcygeus motoneurons. Neurosci Lett. 670:105-109.

2018. Nicolás-Toledo L, Cervantes-Rodríguez M, Cuevas-Romero E, Corona-Quintanilla DL, Pérez-Sánchez E, Zambrano E, Castelán F, Rodríguez-Antolín J. Hitting a triple in the non-alcoholic fatty liver disease field: sucrose intake in adulthood increases fat content in the female but not in the male rat offspring of dams fed a gestational low-protein diet. J Dev Orig Health Dis. 9(2):151-159.

2017. Cuevas-Romero E, Sánchez-Cardiel A, Zamora-Gallegos AM, Cruz-Lumbreras R, Quintanilla DL, Castelán F, Martínez-Gómez M. Moderate-to-high normal levels of thyrotropin is a risk factor for urinary incontinence and an unsuitable quality of life in women over 65 years. Clinical and Experimental Pharmacology and Physiology. 1:86-92


2017. Corona-Pérez, Adriana; Díaz-Muñoz, Mauricio; Cuevas-Romero, Estela; Luna-Moreno, Dalia; Valente-Godínez, Héctor; Vázquez-Martínez, Olivia; Martínez-Gómez, Margarita; Rodríguez-Antolín, Jorge; Nicolás-Toledo, Leticia. Interactive effects of chronic stress and a high-sucrose diet on non-alcoholic fatty liver in young adult male rats. Stress. 20(6):608-617.

2017. Pierlot R, Cuevas Romero E, Rodríguez Antolín J, Méndez Hernández P, Martínez Gómez M. Prevalencia de Síndrome Metabólico en niños y adolescentes de América. TIP Revista Especializada en Ciencias Químico-Biológicas, 20(1): 40-49.

2017. Lara-García M, Alvarado M, Cuevas E, Lara-García O, Sengelaub DR, Pacheco P. Hormonal Treatment Effects on the Cross-sectional Area of Pubococcygeus Muscle Fibers After Denervation and Castration in Male Rats. Anatomical Record Advances in Integrative Anatomy and Evolutionary Biology. 2017 300(7):1327-1335.

2017. Rodríguez-Castelán R, Anaya-Hernández A, Méndez-Tepepa M, Martínez-Gómez M, Castelán F, Cuevas E. Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits. Endocrine Research 42(1):59-70.

2017. Xicohténcatl-Rugerio I, Corona-Quintanilla DL, Nicolás L, Martínez-Gómez M, Cuevas E, Castelán F, Rodríguez-Antolín J. The role of pubococcygeus muscle in the urethrogenital reflex of male rats. Neurourology and Urodynamics. 36(1):80-85.

2017. Rodríguez-Castelán J, Corona-Pérez A, Nicolás-Toledo L, Martínez-Gómez M, Castelán F, Cuevas E. Hypothyroidism induces a moderate steatohepatitis accompanied by liver regeneration, mast cells infiltration, and changes in the expression of the farnesoid X receptor. Experimental and Clinical Endocrinology. 125(3):183-190.

2017. Hernández-Aragón LG, García-Villamar V, Carrasco-Ruiz ML, Nicolás-Toledo L, Ortega A, Cuevas-Romero E, Martínez-Gómez M, Castelán F. Role of Estrogens in the Size of Neuronal Somata of Paravaginal Ganglia in Ovariectomized Rabbits. BioMed Research International. 2017:2089645

2017. Rodríguez-Castelán J, Méndez-Tepepa M, Carrillo-Portillo Y, Anaya-Hernández A, Rodríguez-Antolín J, Zambrano E, Castelán F, Cuevas-Romero E. Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits. Biomed Res Int. 2017;2017:3795950

2016. Sánchez-García O, Rodríguez-Castelán J, Martínez-Gómez M, Cuevas E, Castelán F. Hypothyroidism modifies morphometry and thyroid-hormone receptor expression in periurethral muscles of female rabbits. Neurourology and Urodynamcis. 35:895–901

2016. Corona-Quintanilla DL, López-Juárez R, Zempoalteca R, Cuevas E, Castelán F, Martínez-Gómez M. Anatomic and functional properties supporting bulboglandularis striated muscle support its contribution as sphincter in female rabbit micturition. Neurourology and Urodynamics. 35:689-95.

2016. Díaz-Aguila Y, Castelán F, Cuevas E, Martínez-Gómez M, Rodríguez-Antolín J, Leticia Nicolás-Toledo L. The histomorphological asymmetry of adrenal glands in rats is accentuated by a high-sucrose consumption. Anatomical Science International. 91(2):151-62.

2016. López-García K, Cuevas E, Sánchez-García O, Pacheco P, Martínez-Gómez M, Castelán F. Differential damage and repair responses of pubococcygeus and bulbospongiosus muscles in multiparous rabbits. Neurourol Urodyn. 35(2):180-5.


2015. Corona-Pérez A, Díaz-Muñoz M, Rodríguez IS, Cuevas E, Martínez-Gómez M, Castelán F, Rodríguez-Antolín J, Nicolás-Toledo L. High Sucrose Intake Ameliorates the Accumulation of Hepatic Triacylglycerol Promoted by Restraint Stress in Young Rats. Lipids. 2015 Nov;50(11):1103-13.

2015. Rodríguez-Castelán J, Martínez-Gómez M, Castelán F, Cuevas E. Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits. International Journal of EndocrinologyVolume 2015 (2015), Article ID 917806, 8
 
2015. Carrasco-Ruiz M, García-Villamar V, López-García K, Sánchez-García O, Pacheco P, Cuevas E, Martínez-Gómez M, Castelán F. Aromatase expressed in skeletal muscles relevant for micturition is differentially modulated by long-term ovariectomy and estrogen treatment in rabbits. Cell Biochemistry and Function. 33(4):188-195.

2015. Banderas-Tarabay José Antonio, Cervantes-Rodríguez Margarita, Grada-Sánchez Miriam, Espíndola-Lozano Marlen, Cuevas-Romero Estela, Navarro-Ocaña Arturo, and Méndez-Iturbide Daniel. Antioxidant-mediated protective effect of hawthorn (Crataegus mexicana) peel extract in erythrocytes against oxidative damage. Afr. J. Food Sci. 9(4):208-222.

2015. Rodríguez-Castelán J, Nicolás L, Morimoto S, Cuevas E. The Langerhans islet cells of female rabbits are differentially affected by hypothyroidism depending on the islet size. Endocrine. 48(3): 811-817.

2015. Cuevas E, Martínez-Gómez M, Castelán F. Farnesoid X receptor and reproduction. Receptors & Clinical Investigation 2: e463.

2015. Anaya-Hernández A, Rodríguez-Castelán J, Nicolás L, Martínez-Gómez M, Jiménez-Estrada I, Castelán F, Cuevas E (corresponding autor). Hypothyroidism affects differentially the cell size of epithelial cells among oviductal regions of rabbits. Reproduction in Domestic Animals 50(1):104-11.

2014. González-Quintanilla Y, Cuevas E, Cruz-Lumbreras R, Carrillo-Castilla P, Rodríguez-Antolín J, Martínez-Gómez M. Relación entre células sanguíneas y variables metabólicas en mujeres indígenas de diferentes edades que viven a gran altitud. TIP Revista Especializada en Ciencias Químico-Biológicas 17(2):111-116.

2014. Anaya-Hernández A, Méndez-Tepepa M, Hernández-Aragón LG, Pacheco P, Martínez-Gómez M, Castelán F, Cuevas E. Farnesoid X receptor immunolocalization in reproductive tissues of adult female rabbits.Acta Histochem. 116(6):1068-74

2014. Luna-Vazquez F, Cruz-Lumbreras R, Rodríguez-Castelán J, Cervantes-Rodríguez M, Rodríguez-Antolín J, Arroyo-Helguera O, Castelán F, Martínez-Gómez M, Cuevas E. Association between the serum concentration of triiodothyronine with components of metabolic syndrome, cardiovascular risk, and diet in euthyroid post-menopausal women without and with metabolic syndrome. Springerplus. 24;3:266.

2014. Xelhuantzi N, Rodríguez-Antolín J, Nicolás L, Castelán F, Cuevas E, Martínez-Gómez M. Tissue alterations in urethral and vaginal walls related to multiparity in rabbits. Anat Rec (Hoboken). 297(10):1963-70.

2014. Cervantes M, Martínez-Gómez M, Cuevas E, Nicolás L, Castelán F, Nathanielsz PW, Zambrano E, Rodríguez-Antolín J. Sugared water consumption by adult offspring of mothers fed a protein-restricted diet during pregnancy results in increased offspring adiposity: the second hit effect. British Journal of Nutrition 111(49):616-24.

 2013. Pedrero-Badillo F, Anaya-Hernández A, Corona-Quintanilla DL, Castelán F, Pacheco P, Martínez-Gómez M, Cuevas E MORPHOHISTOLOGICAL CHARACTERISTICS FOR RABBIT OVIDUCT: A PROPOSAL FOR A SINGLE REGIONALIZATION. Animal Science Reproduction, 143:102-1

2013. Alvarado M, Lara-García M, Cuevas E, Berbel P, Pacheco P (2013) DENERVATION AND CASTRATION EFFECTS ON THE CROSS-SECTIONAL AREA OF PUBOCOCCYGEOUS MUSCLE FIBERS IN MALE RATS. The Anatomical Record, 296:1634-1639

2013. López-García K, E Cuevas, Corona-Quintanilla DL, Jiménez-Estrada I, Martínez-Gómez M, Castelán F Effect of multiparity on morphometry and oestrogen receptor expression of pelvic and perineal striated muscles in rabbits: is serum oestradiol relevant? Eur J Obstet Gynecol Reprod Biol. 69:113-120

2013. Castelán F, Xelhuantzi N, Hernández-Aragón L, Rodríguez-Antolín J, Cuevas E, Martínez-Gómez M (2013) MORPHOMETRY OF PARAVAGINAL GANGLIA FROM THE PELVIC PLEXUS: IMPACT OF MULTIPARITY, PRIMIPARITY, AND PREGNANCY. European Journal of Obstetrics and Gynecology and Reproductive Biology, 170:286-292



Últimas Publicaciones / Last Publications
                         2013-2018
Otras LGAC / Other LGAK
Resumen de Curriculum /
Summary of Curriculum