Investigación que realiza / Research focus
La musculatura estriada pélvica y perineal es crítica para la fisiología de la micción femenina. Durante el parto ocurren cambios morfológicos e histológicos que se asocian con condiciones patológicas como la incontinencia urinaria. La gestación, el parto y la lactancia son eventos de la experiencia reproductiva femenina en los que también ocurren cambios endocrinos. En nuestro laboratorio evaluamos la contribución del componente hormonal, asociado a la experiencia reproductiva, sobre la organización celular de músculos pélvicos y perineales. Con tal fin utilizamos métodos histológicos y bioquímicos.

Pelvic and perineal striated musculature is critical for urinary physiology in the female. During childbirth, morphological and histological changes occur that are associated with pathological conditions such as urinary incontinence. Pregnancy, childbirth, and lactation are events of the female reproductive experience that are also associated with endocrine changes. In our laboratory, we evaluate the contribution of the hormonal component of reproductive events on the cellular organization of pelvic and perineal musculature.
Dr. Francisco Castelán
Laboratorio de Biología Celular, Centro Tlaxcala de Biología de la Conducta, UNAM-UATx.
Licenciatura: Químico Farmacéutico Biológo, Universidad Veracruzana

Maestría / Master: Neuroetología, Universidad Veracruzana

Doctorado / Doctorate: Neurociencias y Biología Celular y Molecular, Universidad Miguel Hernández, Alicante, España

Postdoctorado / Postdoctoral Positions: Instituto de Investigaciones Biomédicas, UNAM

Diplomado en Divulgación Científica, UNAM

SNI Nivel I

Sociedades Científicas / Scientific Societies
Socio regular de la Sociedad Mexicana de Ciencias Fisiológicas, A.C. 2008 a la fecha.

Socio regular de la Society for Neuroscience (SFN), de 2009 a la fecha.

Miembro de la Academia de Investigación en Biología de la Reproducción, de 2011 a la fecha.

Socio regular de la International Society for Neurochemistry.

Socio regular de la Sociedad Mexicana de Bioquímica.
En prensa. Yadira Díaz-Aguila, Estela Cuevas-Romero, Francisco Castelán, Margarita Martínez-Gómez, Jorge Rodríguez-Antolín, and Leticia Nicolás-Toledo. Chronic stress and high-sucrose intake elicit distinct effects morphometric in the adrenal gland of post-weaned rats. Journal of Physiological Sciences

En prensa. Rodríguez-Castelán J, Méndez-Tepepa M, Rodríguez-Antolín J, Castelán F, Cuevas-Romero E. Hypothyroidism affects lipid and glycogen content and peroxisome proliferator-activated receptor beta expression in the ovary of the rabbit. Reprod Fertil Dev. 2018 May 3.

2018. García-Villamar V, Hernández-Aragón LG, Chávez-Ríos JR, Ortega A, Martínez-Gómez M, Castelán F. Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and the GDNF Family Receptor Alpha Subunit 1 in the Paravaginal Ganglia of Nulliparous and Primiparous Rabbits. Int Neurourol J. 22(Suppl 1):S23-33.

2018. López-Juárez R, Zempoalteca R, Corona-Quintanilla DL, Jiménez-Estrada I, Castelán F, Martínez-Gómez M. Multiparity modifies contractile properties of pelvic muscles affecting the genesis of vaginal pressure in rabbits. Neurourol Urodyn. 37(1):106-114.

2018. Nicolás-Toledo L, Cervantes-Rodríguez M, Cuevas-Romero E, Corona-Quintanilla DL, Pérez-Sánchez E, Zambrano E, Castelán F, Rodríguez-Antolín J. Hitting a triple in the non-alcoholic fatty liver disease field: sucrose intake in adulthood increases fat content in the female but not in the male rat offspring of dams fed a gestational low-protein diet. J Dev Orig Health Dis. 9(2):151-159.

2017. Cruz Y, Hernández-Plata I, Lucio RA, Zempoalteca R, Castelán F, Martínez-Gómez M. Anatomical organization and somatic axonal components of the lumbosacral nerves in female rabbits. Neurourol Urodyn. 36(7):1749-1756.

2017. López-García K, Mariscal-Tovar S, Serrano-Meneses MA, Castelán F, Martínez-Gómez M, Jiménez-Estrada I. Fiber type composition of pubococcygeus and bulbospongiosus striated muscles is modified by multiparity in the rabbit. Neurourol Urodyn. 36(6):1456-1463.

2017. Suárez-Pozos E, Martínez-Lozada Z, Méndez-Flores OG, Guillem AM, Hernández-Kelly LC, Castelán F, Olivares-Bañuelos TN, Chi-Castañeda D, Najimi M, Ortega A. Characterization of the cystine/glutamate antiporter in cultured Bergmann glia cells. Neurochem Int. 108:52-59.

2017. Rodríguez-Castelán R, Anaya-Hernández A, Méndez-Tepepa M, Martínez-Gómez M, Castelán F, Cuevas E. Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits. Endocrine Research 42(1):59-70.

2017. Xicohténcatl-Rugerio I, Corona-Quintanilla DL, Nicolás L, Martínez-Gómez M, Cuevas E, Castelán F, Rodríguez-Antolín J. The role of pubococcygeus muscle in the urethrogenital reflex of male rats. Neurourology and Urodynamics. 36(1):80-85.

2017. Rodríguez-Castelán J, Corona-Pérez A, Nicolás-Toledo L, Martínez-Gómez M, Castelán F, Cuevas E. Hypothyroidism induces a moderate steatohepatitis accompanied by liver regeneration, mast cells infiltration, and changes in the expression of the farnesoid X receptor. Experimental and Clinical Endocrinology. 125(3):183-190.

2017. Hernández-Aragón LG, García-Villamar V, Carrasco-Ruiz ML, Nicolás-Toledo L, Ortega A, Cuevas-Romero E, Martínez-Gómez M, Castelán F. Role of Estrogens in the Size of Neuronal Somata of Paravaginal Ganglia in Ovariectomized Rabbits. BioMed Research International. 2017:2089645

2017. Rodríguez-Castelán J, Méndez-Tepepa M, Carrillo-Portillo Y, Anaya-Hernández A, Rodríguez-Antolín J, Zambrano E, Castelán F, Cuevas-Romero E. Hypothyroidism Reduces the Size of Ovarian Follicles and Promotes Hypertrophy of Periovarian Fat with Infiltration of Macrophages in Adult Rabbits. Biomed Res Int. 2017;2017:3795950

2016. Sánchez-García O, Rodríguez-Castelán J, Martínez-Gómez M, Cuevas E, Castelán F. Hypothyroidism modifies morphometry and thyroid-hormone receptor expression in periurethral muscles of female rabbits. Neurourology and Urodynamcis. 35:895–901

2016. Corona-Quintanilla DL, López-Juárez R, Zempoalteca R, Cuevas E, Castelán F, Martínez-Gómez M. Anatomic and functional properties supporting bulboglandularis striated muscle support its contribution as sphincter in female rabbit micturition. Neurourology and Urodynamics. 35:689-95.

2016. Díaz-Aguila Y, Castelán F, Cuevas E, Martínez-Gómez M, Rodríguez-Antolín J, Leticia Nicolás-Toledo L. The histomorphological asymmetry of adrenal glands in rats is accentuated by a high-sucrose consumption. Anatomical Science International. 91(2):151-62.

2016. López-García K, Cuevas E, Sánchez-García O, Pacheco P, Martínez-Gómez M, Castelán F. Differential damage and repair responses of pubococcygeus and bulbospongiosus muscles in multiparous rabbits. Neurourol Urodyn. 35(2):180-5.

2015. Corona-Pérez A, Díaz-Muñoz M, Rodríguez IS, Cuevas E, Martínez-Gómez M, Castelán F, Rodríguez-Antolín J, Nicolás-Toledo L. High Sucrose Intake Ameliorates the Accumulation of Hepatic Triacylglycerol Promoted by Restraint Stress in Young Rats. Lipids. 2015 Nov;50(11):1103-13.

2015. E García-Torres, R Hudson, F Castelán, M Martínez-Gómez, A Bautista. 2015. Differential metabolism of brown adipose tissue in newborn rabbits in relation to position in the litter Huddle. Journal of Thermal Biology. 51, 33-41.
2015. Rodríguez-Castelán J, Martínez-Gómez M, Castelán F, Cuevas E. Hypothyroidism Affects Vascularization and Promotes Immune Cells Infiltration into Pancreatic Islets of Female Rabbits. International Journal of EndocrinologyVolume 2015 (2015), Article ID 917806, 8
2015. Carrasco-Ruiz M, García-Villamar V, López-García K, Sánchez-García O, Pacheco P, Cuevas E, Martínez-Gómez M, Castelán F. Aromatase expressed in skeletal muscles relevant for micturition is differentially modulated by long-term ovariectomy and estrogen treatment in rabbits. Cell Biochemistry and Function. 33(4):188-195.

2015. Cuevas E, Martínez-Gómez M, Castelán F. Farnesoid X receptor and reproduction. Receptors & Clinical Investigation 2: e463.

2015. Anaya-Hernández A, Rodríguez-Castelán J, Nicolás L, Martínez-Gómez M, Jiménez-Estrada I, Castelán F, Cuevas E (corresponding autor). Hypothyroidism affects differentially the cell size of epithelial cells among oviductal regions of rabbits. Reproduction in Domestic Animals 50(1):104-11.

2014. Xelhuantzi N, Rodríguez-Antolín J, Nicolás L, Castelán F, Cuevas E, Martínez-Gómez M. Tissue alterations in urethral and vaginal walls related to multiparity in rabbits. Anat Rec (Hoboken). 297(10):1963-70.

2014. Anaya-Hernández A, Méndez-Tepepa M, Hernández-Aragón LG, Pacheco P, Martínez-Gómez M, Castelán F, Cuevas E. Farnesoid X receptor immunolocalization in reproductive tissues of adult female rabbits.Acta Histochem. 116(6):1068-74

2014. Luna-Vazquez F, Cruz-Lumbreras R, Rodríguez-Castelán J, Cervantes-Rodríguez M, Rodríguez-Antolín J, Arroyo-Helguera O, Castelán F, Martínez-Gómez M, Cuevas E. Association between the serum concentration of triiodothyronine with components of metabolic syndrome, cardiovascular risk, and diet in euthyroid post-menopausal women without and with metabolic syndrome. Springerplus. 24;3:266.

2014. Corona-Quintanilla DL, Zempoalteca R, Arteaga L, Castelán F, Martínez-Gómez M. The role of pelvic and perineal striated muscles in urethral function during micturition in female rabbits. Neurourol Urodyn. 33(4):455-60.

2014. Cervantes M, Martínez-Gómez M, Cuevas E, Nicolás L, Castelán F, Nathanielsz PW, Zambrano E, Rodríguez-Antolín J. Sugared water consumption by adult offspring of mothers fed a protein-restricted diet during pregnancy results in increased offspring adiposity: the second hit effect.. British Journal of Nutrition 111(49):616-24.

2013. López-García K, Mariscal-Tovar S, Martínez-Gómez M, Jiménez-Estrada I, Castelán F. Fiber type characterization of striated muscles related to micturition in female rabbits.Acta Histochem. 2013 Nov 11.

2013. Pedrero-Badillo F, Anaya-Hernández A, Corona-Quintanilla DL, Castelán F, Pacheco P, Martínez-Gómez M, Cuevas E MORPHOHISTOLOGICAL CHARACTERISTICS FOR RABBIT OVIDUCT: A PROPOSAL FOR A SINGLE REGIONALIZATION. Animal Science Reproduction, 143:102-1

2013. López-García K, E Cuevas, Corona-Quintanilla DL, Jiménez-Estrada I, Martínez-Gómez M, Castelán F Effect of multiparity on morphometry and oestrogen receptor expression of pelvic and perineal striated muscles in rabbits: is serum oestradiol relevant? Eur J Obstet Gynecol Reprod Biol. 69:113-120

2013. Castelán F, Xelhuantzi N, Hernández-Aragón L, Rodríguez-Antolín J, Cuevas E, Martínez-Gómez M (2013) MORPHOMETRY OF PARAVAGINAL GANGLIA FROM THE PELVIC PLEXUS: IMPACT OF MULTIPARITY, PRIMIPARITY, AND PREGNANCY. European Journal of Obstetrics and Gynecology and Reproductive Biology, 170:286-292

2013. Corona-Quintanilla DL, Zempoalteca R, Arteaga L, Castelán F, Martínez-Gómez M. The role of pelvic and perineal striated muscles in urethral function during micturition in female rabbits. Neurourol Urodyn. 2013 May 1. doi: 10.1002/nau.22416

2013. Bautista A, Castelán F, Pérez-Roldán H, Martínez-Gómez M, Hudson R. Competition in newborn rabbits for thermally advantageous positions in the litter huddle is associated with individual differences in brown fat metabolism. Physiol Behav. 118:189-94.
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