Dra. Leticia Nicolás Toledo


lettita2@yahoo.com


SNI Nivel I

Perfil PROMEP
.
El eje hipotálamo-hipófisis-adrenales (HHA) es de vital importancia, ya que minimiza las desviaciones del estado homeostático. La síntesis y secreción de glucocorticoides (cortisol y corticosterona), representa el paso final de una cascada neuroendocrina que inicia en el sistema nervioso central. El efecto más importante de los glucocorticoides es activar la gluconeogénesis, incrementando la síntesis de las enzimas hepáticas implicadas. Además, estas hormonas esteroídeas actúan sobre el tejido adiposo, efectuando la movilización de aminoácidos para la síntesis de glucosa. El tejido adiposo es el gran reservorio de energía del organismo. Una de las principales funciones de los adipositos, células estructurales del tejido adiposo, es almacenar triglicéridos durante periodos de exceso calórico y movilizar estas reservas cuando el gasto energético excede al consumo. La leptina es la principal hormona sintetizada y secretada por el adipocito en proporción al contenido de grasa corporal y tiene una función inhibitoria sobre el apetito. El eje HHA y el tejido adiposo interaccionan;permanentemente y funcionan en forma coordinada, estas interrelaciones son de enorme complejidad y sólo parcialmente conocidas. En general, los glucocorticoides estimulan la expresión y secreción de leptina, independientemente de los efectos sobre el apetito, ya que se ha propuesto que tal hormona posee una acción inhibitoria sobre el eje HHA. El objetivo de la presente línea de investigación es indagar las consecuencias de un consumo de exceso calórico sobre la glándula adrenal y el metabolismo del tejido adiposo en la rata. Para ello, le ofrecemos a los animales experimentales, después del destete y por dos meses y medio agua azucarada al 5, 15 y 30%. Analizamos la concentración de corticosterona y leptina y hacemos análisis histológicos de la glándula adrenal y del tejido adiposo. Los hallazgos del presente trabajo podrían indicar que los excesos calóricos cotidianos en la dieta pueden promover desordenes metabólicos que conlleven a diferentes cuadros clínicos como la obesidad.



The hypothalamic-pituitary-adrenal axis (HPA) is of vital importance, since it minimizes the deviations from a homeostatic state. The synthesis and secretion of glucocorticoids (cortisol and corticosterone) represents the final step in a neuroendocrine chain that starts in the central nervous system. The most important effect of glucocorticoids is the activation of gluconeogenesis, thereby increasing the synthesis of the implicated hepatic enzymes. Besides, this steroid hormones act on fatty tissue, which starts the mobilization of amino acids in order to synthetize glucose. Fatty tissue is the great reservoir of energy in our organism. One of the main functions of adipocytes, the structural cells of fatty tissue, is to store triglycerides during periods of excessive caloric intake, and also, they mobilize these reserves when the energetic expenditure exceeds the intake of calories. Mainly, leptin is synthetized and secreted by the adipocyte, in proportion to the content of body fat and it has an inhibitory function on appetite. The HPA axis and the fatty tissue interact permanently and work in a coordinated fashion; these interrelationships are incredibly complex and only partially known. In general, glucocorticoids stimulate the expression and secretion of leptin, independently of its effects on appetite, since it has been proposed that such hormone possesses an inhibitory action over the HPA axis. The objective of this research line is to enquire the consequences of excessive caloric intake over the adrenal gland and the metabolism of fatty tissue in rats. To that end, we offer sugared water at 5, 15 and 30% to experimental animals, for a period of two months, and after weaning. We later analyze the concentration of corticosterone and leptine and we carry out histological analyzes of the adrenal gland and the fatty tissue. Our findings indicate that prolonged excessive caloric intake may promote metabolic disorders that entail several health-related problems, such as obesity.
En prensa. Yadira Díaz-Aguila, Estela Cuevas-Romero, Francisco Castelán, Margarita Martínez-Gómez, Jorge Rodríguez-Antolín, and Leticia Nicolás-Toledo. Chronic stress and high-sucrose intake elicit distinct effects morphometric in the adrenal gland of post-weaned rats. Journal of Physiological Sciences

2018. Nicolás-Toledo L, Cervantes-Rodríguez M, Cuevas-Romero E, Corona-Quintanilla DL, Pérez-Sánchez E, Zambrano E, Castelán F, Rodríguez-Antolín J. Hitting a triple in the non-alcoholic fatty liver disease field: sucrose intake in adulthood increases fat content in the female but not in the male rat offspring of dams fed a gestational low-protein diet. J Dev Orig Health Dis. 9(2):151-159.

2017. Corona-Pérez, Adriana; Díaz-Muñoz, Mauricio; Cuevas-Romero, Estela; Luna-Moreno, Dalia; Valente-Godínez, Héctor; Vázquez-Martínez, Olivia; Martínez-Gómez, Margarita; Rodríguez-Antolín, Jorge; Nicolás-Toledo, Leticia. Interactive effects of chronic stress and a high-sucrose diet on non-alcoholic fatty liver in young adult male rats. Stress. 20(6):608-617.

2017. Hernández-Aragón LG, García-Villamar V, Carrasco-Ruiz ML, Nicolás-Toledo L, Ortega A, Cuevas-Romero E, Martínez-Gómez M, Castelán F. Role of Estrogens in the Size of Neuronal Somata of Paravaginal Ganglia in Ovariectomized Rabbits. BioMed Research International. 2017:2089645

2017. Rodríguez-Castelán J, Corona-Pérez A, Nicolás-Toledo L, Martínez-Gómez M, Castelán F, Cuevas E. Hypothyroidism induces a moderate steatohepatitis accompanied by liver regeneration, mast cells infiltration, and changes in the expression of the farnesoid X receptor. Experimental and Clinical Endocrinology. 125(3):183-190.

2017. Xicohténcatl-Rugerio I, Corona-Quintanilla DL, Nicolás L, Martínez-Gómez M, Cuevas E, Castelán F, Rodríguez-Antolín J. The role of pubococcygeus muscle in the urethrogenital reflex of male rats. Neurourology and Urodynamics. 36(1):80-85.

2016. Díaz-Aguila Y, Castelán F, Cuevas E, Martínez-Gómez M, Rodríguez-Antolín J, Leticia Nicolás-Toledo L. The histomorphological asymmetry of adrenal glands in rats is accentuated by a high-sucrose consumption. Anatomical Science International. 91(2):151-62.

2015. Corona-Pérez A, Díaz-Muñoz M, Rodríguez IS, Cuevas E, Martínez-Gómez M, Castelán F, Rodríguez-Antolín J, Nicolás-Toledo L. High Sucrose Intake Ameliorates the Accumulation of Hepatic Triacylglycerol Promoted by Restraint Stress in Young Rats. Lipids. 2015 Nov;50(11):1103-13.

2015. Rodríguez-Castelán J, Nicolás L, Morimoto S, Cuevas E. The Langerhans islet cells of female rabbits are differentially affected by hypothyroidism depending on the islet size. Endocrine. 48(3): 811-817.

2015. Anaya-Hernández A, Rodríguez-Castelán J, Nicolás L, Martínez-Gómez M, Jiménez-Estrada I, Castelán F, Cuevas E (corresponding autor). Hypothyroidism affects differentially the cell size of epithelial cells among oviductal regions of rabbits. Reproduction in Domestic Animals 50(1):104-11.
 
2014. F Aguilar, HG Rödel, J Vázquez, L Nicolas, L Rodríguez-Martínez, Amando Bautista, Margarita Martínez-Gómez. Seasonal changes in testosterone levels in wild Mexican cottontails (Sylvilagus cunicularius). Mammalian Biology-Zeitschrift für Säugetierkunde. 79:225–229

2014. Xelhuantzi N, Rodríguez-Antolín J, Nicolás L, Castelán F, Cuevas E, Martínez-Gómez M. Tissue alterations in urethral and vaginal walls related to multiparity in rabbits. Anat Rec (Hoboken). 297(10):1963-70.

2014. Cervantes M, Martínez-Gómez M, Cuevas E, Nicolás L, Castelán F, Nathanielsz PW, Zambrano E, Rodríguez-Antolín J. SSugared water consumption by adult offspring of mothers fed a protein-restricted diet during pregnancy results in increased offspring adiposity: the second hit effect.. British Journal of Nutrition 111(49):616-24.
Inicio / Home
Otros Investigadores / Other Researchers
Últimas Publicaciones / Last Publications
                       2014-2018
Línea de Generación y Aplicación del Conocimiento (LGAC)/ Line of Generation and Application of Knowledge (LGAK)

 Biomedicina/Biomedicine
LGAC / LGAK
Resumen de Curriculum /
Summary of Curriculum
Investigación que realiza / Research focus
Sociedades Científicas / Scientific Societies